Current Issue : October-December Volume : 2022 Issue Number : 4 Articles : 2 Articles
In this work new azo derivatives of 5-nitroimidazole containing drug moiety were synthesized by reacting metronidazole with various aromatic primary amines to get (compound A1-A4) similarly ornidazole with various diazonium salt to get the (compound B1-B3). Lead compounds were characterized by melting point, TLC, elemental analysis, IR, 1H-NMR and mass spectral data. All the synthesized compounds were screened for their in-vitro antibacterial activity by cup plate method (diffusion technique) showed promising antibacterial activity against standard drug co-trimoxazole. Showed significant antifungal activity against fluconazole as standard drug by diffusion method....
In this work new azo derivatives of anti-inflammatory agents were synthesized by reacting aspirin with nitrating agent to get A1, further treated with various aromatic primary amines to get compound A2-A5. Lead compounds were characterized by melting point, TLC, elemental analysis, IR, 1H-NMR and mass spectral data. All the synthesized compounds were screened for in-vitro anti-inflammatory activity against standard aspirin drug, anthelmintic activity against albendazole as a standard drug. Synthesized compounds showed promising anti-inflammatory and anthelmintic activity....
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